Synthesis of 6-chloro-2-(propargyloxy)quinoline-4-carboxylic acid and propargyl 6-chloro-2-(propargyloxy)quinoline-4-carboxylate

6-Chloro-2-(4-meth­oxy­phen­yl)-4-phenyl­quinoline

In the title compound, C22H16ClNO, the quinoline ring system makes dihedral angles of 56.30 (6) and 7.93 (6)°, respectively, with the adjacent phenyl and benzene rings. The dihedral angle between these phenyl and benzene rings is 56.97 (8)°. In the crystal, weak C-H⋯π and π-π [centroid-centroid distances of 3.7699 (9) and 3.8390 (9) Å] inter-actions link the mol-ecules into a layer parallel to ...

4-Chloro-6-meth­oxy­pyrimidin-2-amine–succinic acid (2/1)

The asymmetric unit of the title compound, 2C5H6ClN3O·C4H6O4, consists of one 4-chloro-6-meth-oxy-pyrimidin-2-amine mol-ecule and one half-mol-ecule of succinic acid which lies about an inversion centre. In the crystal, the acid and base mol-ecules are linked through N-H⋯O and O-H⋯N hydrogen bonds, forming a tape along [1-10] in which R2(2)(8) and R4(2)(8) hydrogen-bond motifs are observed. The...

CAS Name: 4-Chloro-2-methylbenzenamine Synonyms: 2-Amino-5-chlorotoluene; 3-chloro-6-aminotoluene; 4-chloro-2- methylaniline; 4-chloro-6-methylaniline; (4-chloro-2-methylphenyl)amine; 4-chloro-2-toluidine; 4-chloro-ortho-toluidine; 5-chloro-2-aminotoluene; para-chloro-ortho-toluidine; 2-methyl-4-chloroaniline; 2-methyl-4- chlorobenzeneamine

2-Bromo-4-chloro-6-(cyclo­hexyl­imino­meth­yl)phenol

The title compound, C(13)H(15)BrClNO, was prepared by the condensation of equimolar quanti-ties of 3-bromo-5-chloro-salicyl-aldehyde with cyclo-hexyl-amine in methanol. There is an intra-molecular O-H⋯N hydrogen bond in the mol-ecule. The cyclo-hexyl ring adopts a chair conformation.

4 - Chloro - 6 - ethoxy - 2 - ( methylthio ) pyrimidine

4,6-Dichloro-2-(methylthio)pyrimidine (3) reacts with EtONa in EtOH, at ca. 20 ◦C, for 2 h, to give exclusively 4-chloro-6-ethoxy-2-(methylthio)pyrimidine (5) in 89% yield. The latter is presented as a useful multifunctionalised pyrimidine scaffold.